NFL Week 4 anytime touchdown bets are in focus as a loaded Sunday slate features the Colts and Commanders in London, an in-state clash between the Texans and Cowboys in Houston, and a quarterback duel with Trevor Lawrence visiting Joe Burrow in Cincinnati. Derrick Henry also meets his former team, the Tennessee Titans, in a matchup many fans will have circled.
Anytime touchdown wagers remain popular for their plus-money appeal and parlay potential. After cashing on Tee Higgins (+175) and tight end Harold Fannin Jr. (+235) last week, here are five options to consider for Week 4.
Odds courtesy of DraftKings Sportsbook.
NFL Week 4 anytime touchdown bets: Raiders TE Brock Bowers (+160)
The Raiders head into a major test against Patrick Mahomes and the Chiefs at 3-0, though their first three opponents have combined for just one win. Tight end Brock Bowers returned in style last week against the Saints with a game-high 10 catches for 116 yards and a score in a 35-27 victory.
If Las Vegas is going to threaten Kansas City, Bowers, now clearly a top target for Kirk Cousins, should be central again.
2. Bills RB James Cook (-140)
James Cook is rolling. He logged 21 carries for 135 yards and a touchdown in Week 2 against the Lions, then followed with 24 rushes for 154 yards and another score versus the Chargers.
The Patriots arrive shorthanded, with Christian Barmore and Christian Gonzalez out, and are coming off a 29-point loss to the Jaguars. The price is short, but the setup in Buffalo is strong.
3. Vikings RB Aaron Jones (-160)
Value is thin, but the matchup stands out. Miami has yielded six touchdowns to running backs through three games.
Minnesota is a double-digit favorite, with the Dolphins losing De’Von Achane for the season and Brian Flores expected to dial up pressure on his former team. Aaron Jones has not found the end zone since Week 1, but the workload forecast suggests that changes in Week 4.
4. Jets RB Braelon Allen (+115)
Braelon Allen entered the league as a 6-foot-1, 235-pound back and one of the youngest players in his draft class. He produced 482 scrimmage yards and three touchdowns as a rookie, then was limited to four games last year due to injury.
Now making his third career start with Breece Hall sidelined by a quad issue, Allen should see red-zone opportunities against the Bears as Frank Reich leans on his power game.
5. Saints RB Alvin Kamara (+135) (Monday)
The Superdome will commemorate the 20th anniversary of the “Rebirth Game” on Monday night as the Saints host the Falcons. That 23-3 win, sparked by Steve Gleason’s iconic punt block, remains a defining moment for New Orleans.
With Travis Etienne out due to a hamstring injury, Alvin Kamara steps into a prime spot. He is not the same volume machine he once was, but the stage and opportunity align for him to score.
Bonus: Derrick Henry 2 TDs (+250)
Derrick Henry faces the franchise that drafted him No. 45 overall in 2016. While his exit from Tennessee lacked drama, the split was mutual as the Titans slid and Henry chased wins.
Since joining the Ravens in 2024, he leads the NFL with 3,817 rushing yards and 38 rushing touchdowns, outpacing the Titans’ entire offense in both categories over that span. Henry at -210 to score once works as a parlay piece, but the two-touchdown price at +250 is enticing given he is averaging two scores per game this season.
For more angles on this week’s slate, check out our Week 4 NFL odds: Model picks after 10,000 simulations breakdown.
The Saints will host the Falcons at the Caesars Superdome in New Orleans. Betting lines and anytime touchdown prices referenced here are available at DraftKings Sportsbook, one of the largest legal operators in the U.S.
