South Florida vs. UTSA odds headline a Thursday American Athletic Conference matchup as the Bulls travel to San Antonio to face the Roadrunners at the Alamodome. UTSA is 4-1 overall and 1-0 in league play after edging Rice 19-17, while South Florida sits at 4-1 and 1-1 AAC with its lone loss a 17-13 setback to Temple.
South Florida vs. UTSA odds
Kickoff is set for 7:30 p.m. ET at the Alamodome. UTSA is a 7-point favorite and the over/under is 50.5 points. The money line lists UTSA at -278 and South Florida at +225. Last season, USF defeated UTSA 55-23.
Top South Florida vs. UTSA predictions
A projection model that simulates every FBS game 10,000 times indicates value on the total going over 50.5. The Under has hit in three of four UTSA games this season, but this is the lowest total the Roadrunners have seen and more in line with typical South Florida numbers.
The Under is also 3-1 in Bulls games, driven by a defense allowing 14.6 points per game, but the model still forecasts a higher-scoring outcome. South Florida has scored 15 touchdowns this year, 13 on the ground, which could match up well against a UTSA defense allowing 199 rushing yards per contest.
UTSA has been balanced on offense, averaging 5.2 yards per rush, and quarterback Owen McCown has completed 68.2% of his throws for 1,010 yards and seven touchdowns. The model projects 62 total points, identifying the Over as the stronger play roughly 60% of the time.
How to make UTSA vs. South Florida picks
Beyond the total, the projections indicate one side of the spread cashes close to 60% of the time. Bettors weighing the spread may find an edge by aligning with the model’s lean in addition to the total.
Why you can trust the model
The simulation model runs each FBS matchup 10,000 times and entered Week 6 on a profitable 40-35 stretch with top-rated college football selections. Its data-driven approach incorporates efficiency metrics, pace, and matchup tendencies to identify value against the market.
Bettors interested in simulation-based projections can also look to similar work such as Week 4 NFL odds: Model picks after 10,000 simulations for another example of data-driven forecasting.
The Alamodome in San Antonio is a frequent host of major sporting events and more information about the facility can be found via the City of San Antonio. Fans tracking broader college football data and schedules can reference resources from the official NCAA site.













